Light Chromatography Mass Spectometry (LC-MS)
Our LC-MS equipment, available through QIB Extra, offers state-of-the-art technology tailored to meet diverse analytical needs. With advanced features such as high-speed performance, exceptional sensitivity, and versatile detection capabilities, our LC-MS systems are ideal for a range of applications including pharmaceutical analysis, environmental monitoring, and food testing.
Clients can benefit from the precise and reliable results provided by our systems, whether for routine analyses or complex research projects. Access through QIB Extra ensures that you have the support and flexibility needed to leverage this cutting-edge technology effectively. This allows researchers to achieve accurate, high-throughput results and make significant advancements in their fields.
- Waters Xevo TQ Absolute (coupled with the Aquity UPLC I-Class Plus UHPLC System)
The Xevo TQ Absolute, coupled with the Acquity UPLC I-Class Plus UHPLC System, is a top-tier triple quadrupole mass spectrometer offering exceptional analytical performance. It features StepWave™ XS ion transfer optics for enhanced sensitivity, selectivity, robustness, speed, and accuracy.
The LC system operates at up to 1,241 bars with a flow rate of up to 2 mL/min and an injection range of 0.1 to 250 µL. It includes binary solvents, ESI/APCI ion sources, and covers a mass range of 2 to 2048 m/z. MRM speed reaches 500 transitions/s with a polarity switch speed under 20 ms, and scan speed capabilities are up to 10,000 Da/s.
The Xevo TQ Absolute is ideal for both quantitative and qualitative applications, including trace determination of anthocyanins, analysis of short-chain fatty acids, and profiling polyphenols. Its versatility is crucial for bioanalysis, ADME screening, food safety, and environmental monitoring.
- Agilent 6495D Triple-Quadrupole (QQQ) Mass Spectrometer
The 6495D triple-quadrupole (QQQ) mass spectrometer, coupled with the 1290 Infinity II LC System, offers high sample throughput and sensitivity. It complements the 6490 QQQ and provides a robust solution for targeted analysis across various applications.
Operating at up to 1300 bar with a flow rate of up to 5 mL/min and an injection range of 0.1 to 100 µL, the 6495D ensures flexibility and efficiency. It uses a binary solvent system and features an ESI ion source with Jet Stream and iFunnel technology, achieving detection limits down to ppq levels. The mass range is 5 to 3000 m/z, with an MRM speed of 700 transitions/s, a polarity switch speed under 25 ms, and a scan speed of 18,700 Da/s.
The 6495D excels in applications like analysing Vitamin B12 in plants, trimethylamine N-oxide in human plasma, and amino acids in cell culture. Its advanced capabilities ensure precise and reliable results for demanding analyses.
- Agilent Infinity 12Cut90II LC/MSD XT
The Agilent Infinity 1290II LC/MSD XT system is optimised for large molecule analysis in pharmaceutical, synthetic chemistry, and food testing. This high- speed, single quadrupole mass analyser excels in biomolecule analysis and high-throughput screening.
With a maximum pressure of 1300 bar and a flow rate of up to 5 mL/min, it offers versatility and efficiency. The system supports an injection range of 0.1 to 100 µL and uses a binary solvent system. Equipped with an ESI ion source with Jet Stream technology, it covers a mass range from 2 to 3000 m/z, with a SIM dwell time of 5 ms, a polarity switch speed under 30 ms, and a scan speed of 10,400 Da/s.
The Infinity 1290II LC/MSD XT is ideal for isolating anthocyanins and their breakdown products in complex samples, providing precise and reliable results for demanding large molecule analyses.
- 1290 Infinity II LC System
The 1290 Infinity II LC System is a high-performance ultra-high pressure liquid chromatography (UHPLC) instrument offering excellent resolution, high peak capacity, and low carryover. It is ideal for UHPLC applications where mass spectrometry is not needed, with flexibility for various analytes and applications. It features refractive index (RID), fluorescence (FLD), and diode array detection (DAD).
Operating at up to 1300 bar with a flow rate up to 5 mL/min, it supports injections from 0.1 to 100 µL and uses a binary solvent system. Its advanced detection capabilities make it well-suited for applications like determining procyanidins in apple extracts.
The 1290 Infinity II LC System delivers high performance and precise detection, ensuring accurate and reliable results for your analytical needs and project success.
- Waters Alliance HPLC System
The Waters Alliance HPLC System is a trusted high-performance liquid chromatography platform. It features a robust quaternary pump for consistent flow rates and retention times, and is equipped with a Refractive Index Detector (RID) for reliable results across various applications.
Operating at up to 5,000 psi and a flow rate of up to 10 mL/min, the system offers versatility and efficiency. The sample compartment maintains a temperature range of 4–40 °C, and the quaternary pump provides flexible solvent delivery for complex separations.
Ideal for projects requiring precision and reliability, the Alliance HPLC System is well-suited for analysing carbohydrate content in food products. Its advanced features ensure accurate and consistent results, making it a valuable tool for high-quality HPLC analysis.
For more information on how our advanced LC-MS access services can enhance your research, please visit our contact form. If you are interested to learn more about how our team would use the equipment for a research project, please visit our polyphenol and bioanalysis service pages. Additionally, if you need bioanalysis consultancy services for polyphenols, short-chain and long-chain fatty acids, anthocyanin, and other topics, please visit our bioanalysis consultancy page.
Our team is eager to answer any questions and offer the expert support you need to maximise the potential of our equipment and services. We look forward to working with you to achieve your research objectives.
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